After analyzing the 16 games on the Week 4 slate in the NFL, our best against-the-spread selection is Raiders -1. For more tips, which could lead to parlay opportunities, scroll down.

NFL Picks Against the Spread – Week 4

Jump to Matchup:

Pick: Raiders -1 vs. Browns

• Matchup: Cleveland Browns at Las Vegas Raiders
• Projected Winner & Margin: Raiders by 6.3 points (Bet on this game at BetMGM)
• Spread: Raiders -1
• Time: 4:25 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Saints +1.5 vs. Falcons

• Matchup: New Orleans Saints at Atlanta Falcons
• Projected Winner & Margin: Saints by 0.4 points (Bet on this game at BetMGM)
• Spread: Falcons -1.5
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Dolphins +1.5 vs. Titans

• Matchup: Tennessee Titans at Miami Dolphins
• Projected Winner & Margin: Dolphins by 5.0 points (Bet on this game at BetMGM)
• Spread: Titans -1.5
• Time: 7:30 PM ET
• Date: Sept. 30
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Steelers -2 vs. Colts

• Matchup: Pittsburgh Steelers at Indianapolis Colts
• Projected Winner & Margin: Steelers by 4.5 points (Bet on this game at BetMGM)
• Spread: Steelers -2
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Buccaneers +2.5 vs. Eagles

• Matchup: Philadelphia Eagles at Tampa Bay Buccaneers
• Projected Winner & Margin: Buccaneers by 2.5 points (Bet on this game at BetMGM)
• Spread: Eagles -2.5
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Vikings +2.5 vs. Packers

• Matchup: Minnesota Vikings at Green Bay Packers
• Projected Winner & Margin: Packers by 1.2 points (Bet on this game at BetMGM)
• Spread: Packers -2.5
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Bills +2.5 vs. Ravens

• Matchup: Buffalo Bills at Baltimore Ravens
• Projected Winner & Margin: Ravens by 1.0 points (Bet on this game at BetMGM)
• Spread: Ravens -2.5
• Time: 8:20 PM ET
• Date: Sept. 29
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Rams +3 vs. Bears

• Matchup: Los Angeles Rams at Chicago Bears
• Projected Winner & Margin: Rams by 1.1 points (Bet on this game at BetMGM)
• Spread: Bears -3
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Cardinals -3.5 vs. Commanders

• Matchup: Washington Commanders at Arizona Cardinals
• Projected Winner & Margin: Cardinals by 7.3 points (Bet on this game at BetMGM)
• Spread: Cardinals -3.5
• Time: 4:05 PM ET
• Date: Sept. 29
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Seahawks +3.5 vs. Lions

• Matchup: Seattle Seahawks at Detroit Lions
• Projected Winner & Margin: Lions by 2.9 points (Bet on this game at BetMGM)
• Spread: Lions -3.5
• Time: 8:15 PM ET
• Date: Sept. 30
• TV Channel: ABC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Panthers +4.5 vs. Bengals

• Matchup: Cincinnati Bengals at Carolina Panthers
• Projected Winner & Margin: Panthers by 0.9 points (Bet on this game at BetMGM)
• Spread: Bengals -4.5
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Giants +5.5 vs. Cowboys

• Matchup: Dallas Cowboys at New York Giants
• Projected Winner & Margin: Cowboys by 1.1 points (Bet on this game at BetMGM)
• Spread: Cowboys -5.5
• Time: 8:15 PM ET
• Date: Sept. 26
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Texans -7 vs. Jaguars

• Matchup: Jacksonville Jaguars at Houston Texans
• Projected Winner & Margin: Texans by 8.5 points (Bet on this game at BetMGM)
• Spread: Texans -7
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Broncos +7.5 vs. Jets

• Matchup: Denver Broncos at New York Jets
• Projected Winner & Margin: Broncos by 1.3 points (Bet on this game at BetMGM)
• Spread: Jets -7.5
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Chargers +8 vs. Chiefs

• Matchup: Kansas City Chiefs at Los Angeles Chargers
• Projected Winner & Margin: Chargers by 2.4 points (Bet on this game at BetMGM)
• Spread: Chiefs -8
• Time: 4:25 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: 49ers -10 vs. Patriots

• Matchup: New England Patriots at San Francisco 49ers
• Projected Winner & Margin: 49ers by 10.6 points (Bet on this game at BetMGM)
• Spread: 49ers -10
• Time: 4:05 PM ET
• Date: Sept. 29
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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